Posts tagged with placebo


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ECT – good or bad?

March 4, 2011 by .

The American Psychiatric Association (APA) has been arguing in favour of ECT as a safe treatment for severe mental illness, according to a short piece in the current issue of the BPS magazine The Psychologist. The APA claims that ECT is effective 80% of the time and there is no evidence for any associated brain damage.

On the other hand a recent review by Bentall and Read (2010, see here) concluded that any benefits of ECT, when they arise, are minimal, short-lived and come with a significant risk of memory impairment and a slight risk of death. This conclusion was based on a review of studies over the last 60 years where the use of ECT for depression or schizophrenia was compared to a placebo control procedure. Bentall and Read’s final word is that the evidence is so poor that it’s use cannot be scientifically-justified.

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The Placebo Effect… the A02 point that just keeps getting bigger….

October 17, 2009 by .

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“Some products that have been on the market for decades, like Prozac, are faltering in more recent follow-up tests. In many cases, these are the compounds that, in the late 90s, made Big Pharma more profitable than Big Oil. But if these same drugs were vetted now, regulators might not approve some of them. Two comprehensive analyses of antidepressant trials have uncovered a dramatic increase in placebo response since the 80s. One estimated that the so-called effect size (a measure of statistical significance) in placebo groups had nearly doubled over that time. It’s not that the old meds are getting weaker, drug developers say. It’s as if the placebo effect is somehow getting stronger.”

Read whole article here

Picture link here